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    Lobular Carcinoma in Situ

    Overview
    Causes
    Symptoms
    Risk Factors
    Prevention
    Diagnosis
    Treatment
    Where to Seek Treatment

    Contributed by:
    SingHealth Duke-NUS Breast Centre



    Overview

    Lobular carcinoma in situ (LCIS) is caused by abnormal cells forming within the milk glands (lobules) in the breast. It is most common in women between the ages of 40 and 50. LCIS is not a cancer but it does increase the risk of developing breast cancer.

    Causes

    There are no known causes.

    Symptoms

    LCIS by itself does not usually cause symptoms but it is usually diagnosed after a biopsy is done for some other reason. In more than 50 percent of cases, LCIS may be multifocal, that is multiple lobules may have areas of abnormal cell growth.

    Risk Factors

    Risk factors include:

    • A family history of breast cancer
    • Taking hormonal replacement therapy (HRT) for menopause

    Diagnosis

    LCIS is commonly an incidental finding on biopsy of the breast for another reason.

    Treatment

    Management of LCIS includes:

    • Close observation e.g. clinical breast examinations, annual mammograms or MRI of the breasts.
    • Chemoprevention, which is taking medication to reduce the risk of cancer. These drugs may include Tamoxifen or Raloxifene for 5 years.
    • Surgery, where preventive or prophylactic mastectomy may be considered if there is a high risk based on a strong family history of breast cancer or if there is a BRCA gene mutation.

    Cancer Risk
    There is an increase of 20 percent cancer risk over 15 years at the point of diagnosis.

    Where to Seek Treatment

    Specialist services available at the SingHealth Duke-NUS Breast Centre located at:

    National Cancer Centre Singapore Tel: 6436 8088
    Singapore General Hospital Tel: 6321 4377
    Changi General Hospital Tel: 6850 3333
    Sengkang General Hospital Tel : 6930 6000
    KK Women's and Children's Hospital Tel: 6294 4050

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